12/8/2022 0 Comments Amniotic fluid levels![]() ![]() Congenital heart disease in monochorionic twins with and without twin-to-twin transfusion syndrome. Springer S, Mlczoch E, Krampl-Bettelheim E, et al. Influence of twin-twin transfusion syndrome on fetal cardiovascular structure and function: prospective case-control study of 136 monochorionic twin pregnancies. Karatza AA, Wolfenden JL, Taylor MJ, et al. AMNIOTIC FLUID LEVELS TRIALThis study was registered with Japanese Clinical Trial Registry “UMIN-CTR” ( trial ID numbers UMIN000024437702). The recipient twin with an increased DV-PI is expected to be under a high cardiac load therefore, DV-PI is a useful parameter for assessing increased NT-proBNP levels consecutively and noninvasively. ConclusionĪ positive correlation between the DV-PI and afNT-proBNP levels of recipient twins with TTTS was observed. ![]() The Doppler parameters of donor twins were scarcely correlated with the afNT-proBNP levels of the recipient twins. The afNT-proBNP levels of the recipient twins showed a stronger correlation with the DV-PI ( r = 0.637 P < 0.001) of recipient twins than with the UA-PI and MCA-PI of recipient twins. ResultsĪ total of 150 MD twin pregnancies were included. The Spearman or Pearson correlation coefficients were used to assess the relationships between afNT-proBNP levels and Doppler parameters. ![]() The afNT-proBNP levels of recipient twins were examined at the time of surgery. Doppler flow was used to measure the pulsatility index (PI) of the umbilical artery (UA), ductus venosus (DV), and middle cerebral artery (MCA) of each recipient and donor twins. This single-center, prospective study included all monochorionic diamniotic (MD) twin pregnancies that were diagnosed with TTTS and underwent fetoscopic laser surgery. This study examined the relationships between fetal quantitative Doppler parameters and amniotic fluid N-terminal prohormone brain natriuretic peptide (afNT-proBNP) levels as a biomarker of the increased cardiac load in recipient twins with twin-to-twin transfusion syndrome (TTTS). ![]()
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